Our current priority areas based on the research framework are listed below. More details on projects coming soon. Please contact us if you would like to learn more.
- Femoroacetabular Impingement and hip osteoarthritis
- Post-traumatic knee osteoarthritis
- Community-based movement retraining intervention for people with knee osteoarthritis
- Menopause and risk of knee osteoarthritis.
Role of thigh muscle intramuscular fat in knee osteoarthritis
The objective was to compare thigh muscle intramuscular fat (intraMF) fractions and area between people with and without knee radiographic osteoarthritis (ROA); and to evaluate the relationships of quadriceps adiposity and area with strength, function and knee magnetic resonance imaging (MRI) lesions. The ROA group had greater quadriceps intraMF fraction but not for other muscles. Quadriceps strength was lower in ROA group but the area was not different. Quadriceps intraMF fraction but not area predicted self-reported disability. Aging, worse KL, and cartilage and meniscus lesions were associated with higher quadriceps intraMF fraction.
(PI: Richard B Souza, Sharmila Majumdar)
Kumar et al. Osteoarthritis Cart 2014
Estimates of joint loading during walking in knee osteoarthritis
The objective was to estimate medial and lateral loading for people with knee OA and controls using an approach that is sensitive to subject specific muscle activation patterns. OA subjects walked slower and had greater laxity, static and dynamic varus alignment, less flexion and greater knee adduction moment (KAM). OA subjects had greater absolute medial load than controls and maintained a greater %total load on the medial compartment. These patterns were associated with body mass, sagittal and frontal plane moments, static alignment and close to significance for dynamic alignment. Lateral compartment unloading during mid-late stance was observed in 50% of OA subjects.
(PI: Katy Rudolph, Kurt Manal, Thomas Buchanan)
Kumar et al. Osteoarthritis Cart 2013
Kumar et al. J Orthop Res 2012
Neuromuscular adaptation in people with knee osteoarthritis
The aim of this study was to analyze neuromotor adaptation during walking in people with knee OA and controls in response to walking perturbations. Subjects with OA walked with less knee motion and higher muscle activation and had greater pain, limitations in function, quadriceps weakness, and malalignment, but no difference was observed in proprioception. Both groups showed increased EMG and decreased knee motion in response to the first perturbation, followed by progressively decreased EMG activity and increased knee motion during midstance over the first five perturbations, but no group differences were observed. Over 30 trials, EMG levels returned to those of normal walking. The results illustrate that people with knee OA respond similarly to healthy individuals when exposed to challenging perturbations during functional weight-bearing activities despite structural, functional, and neuromotor impairments.
(PI: Katy Rudolph)
Kumar et al. J Applied Physiol 2014